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Notch Signaling Pathway EpiTect ChIP qPCR Array 

Notch信号通路ChIP qPCR芯片
 

ProductSpeciesTechnologyCat. No.Notch Signaling Pathway EpiTect ChIP qPCR ArrayHumanHistone ModificationsGH-059ANotch Signaling Pathway EpiTect ChIP qPCR ArrayMouseHistone ModificationsGM-059A

The Human Notch Signaling Pathway EpiTect ChIP qPCR Array profiles the histone modification status or “histone code” of 84 genes key to Notch signal transduction. Histone modifications regulate chromatin structure and correlate with the transcriptional activity of associated genes. The Notch pathway includes 4 Notch receptors that are activated by ligands from the Jagged and Delta families. These receptors are cleaved and translocate to the nucleus, where they interact with co-activator and co-repressor complexes to control target genes. Histone modifications epigenetically regulate some Notch target genes, affecting their ability to be induced or repressed by Notch. Core Notch signaling genes may be regulated in a similar manner. Notch signaling mediates cell–cell communication and developmental processes, and interacts with other developmental signaling pathways such as Hedgehog and Wnt. This array includes genes involved in Notch signaling as well as Notch targets. Genes from other signaling pathways that cross-talk with the Notch signaling pathway are also represented. Using chromatin immunoprecipitation and this real-time PCR array, research studies can easily and reliably analyze the histone modification patterns associated with a focused gene panel involved in Notch signaling.
Notch信号通路ChIP qPCR芯片分析Notch信号通路84个关键基因的组蛋白修饰状态或组蛋白密码。组蛋白修饰调节染色质结构和与相关基因的转录活性。Notch通路包括四个Notch受体，他们被来自Jagged 和Delta家族的配体激活。这些受体裂开转入细胞核，在细胞核中与辅激活子和辅抑制因子复合体共同作用控制目标基因。组蛋白修饰表观遗传调节某些Notch靶标基因,影响他们被诱导的能力或Notch抑制。Notch信号核心基因的调节方式可能也与之类似。Notch信号介导细胞间通讯和发育过程,并与其他信号通路相互作用，如Hedgehog 和Wnt信号通路。这个芯片包含了参与Notch信号的基因，及其靶标基因。还包括与Notch交互作用的其他信号通路基因。通过染色质免疫沉淀和EpiTect ChIP qPCR芯片，可以很简易、可靠地分析组蛋白的化学修饰模式与Notch信号通路相关基因的关联。
 
EpiTect ChIP qPCR仅用于分子生物学应用。本产品不用于疾病的诊断、预防和治疗。
 
Notch Signaling Pathway:
Notch Ligands and Cofactors: ADAM17 (CD156B), JAG2, LFNG, MFNG, NOTCH1, NOTCH2, NOTCH3, NOTCH4, RFNG.
Notch Receptor Processing: ADAM10, APH1A, DTX1, DVL1, NCSTN, NUMB, PSEN1, PSEN2, PSENEN (PEN2).
Notch Transcription Factors and Cofactors: KAT2B, MAML1, MAML2, NCOR2, RBPJL, SNW1 (SKIIP).
Notch Signaling Pathway Target Genes:
Apoptosis Genes: CDKN1A, CFLAR (CASH), IL2RA, NFKB1, PTCRA.
Cell Cycle Regulators: CCND1, CDKN1A, IL2RA.
Cell Proliferation: CDKN1A, ERBB2, FOSL1, IL2RA.
Genes Regulating Cell Differentiation: DTX1, PPARG.
Neurogenesis: HES1, HES5, HEY1, HEY2.
Regulation of Transcription: DTX1, FOS, FOSL1, HES1, HES5, HEY1, HEY2, ID1, NFKB1, NFKB2, NR4A2, PPARG, STAT6.
Immune Response: CHUK, IFNG, IL17B, NFKB1.
Other Target Genes with Unspecified Functions: CD44, KRT1, LOR.
Notch Signaling Processes:
Apoptosis: AXIN1, EP300, HDAC1, NOTCH2, PSEN1, PSEN2.
Cell Cycle Regulators: AXIN1, CCNE1, EP300, FIGF (VEGFD), JAG2, KAT2B, NOTCH2.
Cell Proliferation: FIGF, FZD3, JAG2, KAT2B, LRP5, MMP7, NOTCH2, STIL (SIL).
Regulation of Cell Differentiation: JAG2, LMO2, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PAX5, SHH.
Neurogenesis: EP300, HEYL, NEURL, NOTCH2, PAX5, RFNG.
Regulation of Transcription: AES (GRG5), CBL, CTNNB1, EP300, GLI1, HDAC1, HEYL, HR, KAT2B, NCOR2, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PAX5, POFUT1, RUNX1, SUFU, TEAD1, TLE1.
Immune Response:GBP2, IL2RA, SH2D1A.
Other Gene:SEL1L.
Other Signaling Pathways that Crosstalk with the Notch Signaling Pathway:
Sonic Hedgehog (Shh) Pathway: GLI1, GSK3B, SHH, SMO, SUFU.
Wnt Receptor Signaling Pathway: AES (GRG5), AXIN1, CTNNB1, FZD1, FZD2, FZD3, FZD4, FZD6, FZD7, GSK3B, LRP5, TLE1, WISP1, WNT11.

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途