One of the dominant approaches in synthetic biology is the development and implementation of minimal circuits that generate reproducible and controllable system behavior. However, most biological systems are highly complicated and the design of sustainable minimal circuits can be challenging. SobolHDMR is a general-purpose metamodeling software that can be used to reduce the complexity of mathematical models, such as those for metabolic networks and other biological pathways, yielding simpler descriptions that retain the features of the original model. These descriptions can be used as the basis for the design of minimal circuits or artificial networks.