活体动物体内成像技术文献-3
1. Systemic tumor targeting and killing by Sindbis viral vectors
NATURE BIOTECHNOLOGY 22 (1): 70-77, January 2004
本文依据Sindbis病毒对癌细胞表面超量表达的LAMR的识别的机理，以荧光素酶基因分别标记病毒和癌细胞, 观察标记的病毒在体内对癌细胞的靶向识别和特异性杀伤, 以及标记的癌细胞在体内被病毒侵染后的凋亡和消除。文中还利用标记的病毒检测到卵巢癌细胞在网膜、膈膜与肠系膜等处的微小转移灶。
2. Bioluminescence Imaging Reveals Systemic Dissemination of Herpes Simplex Virus Type 1 in the Absence of Interferon Receptors
JOURNAL OF VIROLOGY Vol.77, No.20, p.11082-11093, Oct. 2003
观察以荧光素酶基因标记的疱疹病毒在不同干扰素受体敲除转基因小鼠体内的复制和侵染过程， 以此研究一型和二型干扰素受体在病毒侵染过程中的不同作用机理。
3. Optimization of Adenoviral Vectors to Direct Highly Amplified Prostate Specific Expression for Imaging and Gene Therapy
MOLECULAR THERAPY Vol. 8, No. 5, November 2003
本文研究以腺病毒作为基因治疗载体的最佳条件。利用两步激活放大系统和前列腺组织特异性启动子，观察作为标记蛋白的荧光素酶在活体动物的前列腺细胞的特异和高效表达。
4. RNA interference in adult mice
NATURE Vol. 418, pp 38, July 4 , 2002
在活体动物体内研究及观察不同特异性的阻断RNA对荧光素酶基因和 HCV(丙肝病毒)基因在体内表达的阻断作用。
5. Bovine Herpes virus Tegument Protein VP22 Enhances Thymidine Kinase/Ganciclovir Suicide Gene Therapy for Neuroblastomas Compared to Herpes Simplex Virus VP22
Journal of Virology, Vol. 78, No. 8, Feb. 2004, p.4224-4233
6. Noninvasive Imaging of Cathionic Lipid-Mediated Delivery of Optical and PET Reporter Genes in Living Mice
Molecular Therapy, Vol. 6, No. 4, October 2002, p. 555
7. Optical Imaging of Transferrin Targeted PEI/DNA Complexes in living subjects
Gene Therapy, 2003, 10, 758-764
