紫杉醇的制剂杂质方法
制剂
紫杉醇注射液
杂质
质Ⅰ, (三尖杉宁碱H3CAOHom〈McCHH3CCHoH =HC45H53NO14831.91 杂质Ⅱ, (7-表-10-去乙酰基紫杉醇) H OH H3C CH3CH3H C45H49NO13811.87 (2aR,4R,4aS,6R,9S,11S,12aR,12bS)-1,24a,6,9,10,11,12,12a,12b十二氢4,6,9,11,12,12b六羟基4a,8,13,13-四甲基7,11-亚甲基5H-环芳癸[3,4]苯并[1,2-b]氧杂环丁烷-5酮-12b醋酸酯,12-苯甲酸酯,9-(2R3S)-N-苯甲酰-3-苯基异丝氨酸酯杂质Ⅲ(7-表紫杉醇)HCH H OH HgC mMoh CH3 CHaah H三HCH3 C47H51NO14853.91 (2aR,4R,4aS,6R,9S,11S,12aR,126S)-1,2a,3,4,4a,6,9,10,11,12,12a,12b+二氢4,6,9,11,12,12b-六羟基4a,8,13,13-四甲基7,11-亚甲基5H-环芳癸[3,4]苯并[1,2-b]氧杂环丁烷-5酮-6,12b-二醋酸酯,12-苯甲酸酯,9-(2R,3S)-N-苯甲酰-3-苯基异丝氨酸酯
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