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BCEIA 2023 ‖ 学术报告会大会报告 2

2023.6.19

BCEIA 2023预登记通道：http://t2.eainfor.com/T/p/103_6

　　语言：英文

　　时间：2023年9月6日

　　地点：学术会议区W201

　　邀请全球知名科学家介绍DNA存储、纳米毒理学等前沿科学技术，分享球差电镜、微型化双光子显微镜等高端仪器的研究进展，同时就质谱法和核磁共振法等研究生物大分子结构及功能、新型分离介质制备及蛋白药物、疫苗纯化等最新应用进行探讨和展望。

　　Oliver J. Schmitz

　　教授德国杜伊斯堡-埃森大学

　　报告题目：Development of a New Ionization Source for Single Cell Metabolome Analysis

　　报告摘要

　　Although the unrevealing of cellular heterogeneity is limiting for the understanding of complex processes in cancer research as e.g. its influence on the process of metastasising, current research still depends on bulk analysis technologies as no reliable method could be established for real single cell metabolome analysis yet.

　　The necessary analytical requirements that such a method for single cell metabolome analysis needs in terms of detection limit, sample amount and specificity will be discussed in detail in this presentation. Also, still unsolved problems will be addressed and put up for discussion.

　　Subsequently, our current work on an ion source, which should be able to destroy the cell and thus release the analytes and ionize them by means of Dielectric Barrier Discharge, will be presented. The current status of developments from the literature and from us will be briefly presented in this talk.

　　个人简介

　　In 2009 Oliver J. Schmitz got a full professor in Analytical Chemistry at the University of Wuppertal (BUW). Between 2010 and 2012 he was the chair of the Analytical Chemistry department at BUW. Since 2013, Schmitz has been a full professor at the University of Duisburg-Essen and heads the Institute for Applied Analytical Chemistry.

　　2009 he cofounded the company iGenTraX UG which develops new ion sources and units to couple separation techniques with mass spectrometers. In 2011 he was one of the founding directorsof the Interdisciplinary Centre for Pure and Applied Mass Spectrometry, University of Wuppertal. Since 2013, Schmitz is also one of the chairmen of the analytica conferences in China and Vietnam and in 2018, together with Agilent Technologies, he founded the Teaching and Research Center for Separation (TRC).

　　The research fields of Prof. Schmitz are the development of ion sources, use and optimization of multi-dimensional LC and GC, ion mobility-mass spectrometry and coupling analytical techniques with mass spectrometers. Furthermore, he is working about origin of life and metabolomics. Prof. Schmitz was awarded the scholar-in-training award of the American Association for Cancer Research in 2003, the Gerhard-Hesse Prize for chromatography in 2013 and in the same year the Fresenius Lecturer. 2018 he was awarded with the Waksmundzki Medal Award for Analytical Chemistry of the Polish Academy of Sciences.

　　马光辉

　　中国科学院院士

　　美国医学与生物工程院（AIMBE）fellow

　　中国科学院过程工程研究所研究员

　　生化工程国家重点实验室主任

　　中国颗粒学会副理事长

　　中国化学会会士

　　中国化工学会会士

　　中国微米纳米技术学会会士

　　中国化工学会生物化工专业委员会副主任委员

　　中国生物工程学会生物基材料专业委员会主任委员

　　报告题目：新型分离介质的制备和蛋白药/疫苗纯化应用Preparation of Novel Microspheres for Protein / Vaccine Separation Application

　　Polysaccharide particles such like agarose particles have been widely used in protein separation and purification as chromatographic packing materials by biological scientists and in industry. However, the limitation of conventional agarose particles is that the separation resolution is limited due to their broad size distribution. Furthermore, the particles with large size are usually used for industrial separation and purification to avoid the increase of back-pressure, which also limit the separation resolution. On the other hand, the particulate vaccine such like virus-like particle (VLP) has attracted more and more attention, conventional agarose particles with small pore size not only limited the adsorption of VLP, but also enhanced the disassociation of VLP, resulting very low activity recovery of VLP.We have developed a novel membrane process to prepare uniform agarose particle. By this technique we can control the CV (coefficient of variation) value which representing the size distribution around 15%, and we can prepare small uniform particles with high agarose concentration. Therefore, we can use small particles instead of large particles, and increase the separation resolution and flow rate of chromatography. We have developed a new process to prepare giga-porous particle with pore size controllable between 100nm to 500 nm, and we found that it not only increased the loading amount of VLP, but also avoided the disassociation of VLP. This was because large pore size weakened the multi-site interaction between VLP and pore. This novel particle has been used for production of particulate vaccine instead of ultra-high speed centrifugation technique, much higher recovery was achieved.

　　个人简介

　　马光辉，中国科学院院士，美国医学与生物工程院（AIMBE）fellow，生化工程国家重点实验室主任。国家杰出青年获得者，基金委创新群体首席，中国颗粒学会副理事长，中国化学会会士、中国化工学会会士、中国微米纳米技术学会会士、中国化工学会生物化工专业委员会副主任委员、中国生物工程学会生物基材料专业委员会主任委员。研究方向为均一生物微球和微囊的制备及其在生化工程和医学工程中的应用，研究和开发用于生化分离、药物载体、免疫佐剂（疫苗递送系统）、细胞培养微载体、酶固定化载体等创新产品。在Nat. Mater., Sci. Transl. Med., Nat. Nanotechnol., Nat. Biomed. Eng., Sci. Adv., Nat. Commun., JACS, Adv. Mater.等国际著名学术期刊上发表SCI论文500余篇。出版中英文专著12部，撰写学术书章节22篇。中国发明专利授权81项，国际专利授权12项，专利技术和产品在国内外500多家单位得到应用。获国家技术发明二等奖、北京市科学技术一等奖、中国化工学会科学技术奖基础研究成果奖一等奖、中国颗粒学会自然科学奖一等奖、中国石油和化学工业联合会技术发明一等奖、侯德榜化工科技创新奖、“中国科协全国优秀科技工作者”称号。

　　程和平

　　中国科学院院士

　　北京大学未来技术学院教授

　　北京大学分子医学南京转化研究院院长

　　北京大学国家生物医学成像科学中心主任

　　国家十三五重大科技设施“多模态跨尺度生物医学成像设施” 首席科学家

　　报告题目：科技铸器，开启脑科学研究新范式

　　脑科学研究包括“读、释、写、仿”四个方面，是一门高度交叉的新兴前沿学科。为开发“读、释、写、仿”工具，团队于2017年成功研发了2.2克微型化双光子显微镜，实现了在自由行为小鼠观察大脑神经元活动，开启脑科学研究的新范式。2021年，第二代微型化双光子显微镜问世，实现了三维空间中近千个神经元的功能成像，开启了在自由行为动物研究大脑神经元结构和功能的新范式。2023年成功研发了2.17克的微型化三光子显微镜，首次实现对自由行为中小鼠的大脑全皮层和海马神经元功能成像，为揭示大脑深部神经机制提供了又一利器。为支撑中国的“脑计划”，我们建设了“南京脑观象台”，由相关领域专家领衔，正在开展脑科学“探索计划”项目，主题涉及皮质工作记忆、睡眠、自闭症、抑郁症、神经药理学和神经元再生等。作为国之重器，“多模态跨尺度生物医学成像设施”（国家十三五重大科技基础设施）的建设正在如火如荼地展开，预期于今年底投入试运行，2024年完成国家验收。依托此成像大设施，已启动“早鸟项目”，面向全国科技界滚动征集合作立项建议，计划在未来3-5年内发起生命科学包括脑科学领域的大科学计划，充分发挥“科技航母”的战略价值。大科学时代的生命科学特别需要新的工具，需要新型的研究平台。未来，更多新工具的开发以及新范式的探索，特别是大科学时代有组织科研的新范式，将为提升我国生物医学研究的整体水平，尤其是原始创新能力，实现高端生物医学仪器装备的“中国创造”提供强有力的战略支撑和保障。

　　个人简介

　　程和平院士长期致力于钙信号、线粒体生物医学领域的研究，以及高端生物医学仪器的自主创制。主要学术贡献为 ① 发现细胞钙信号基本单位—“钙火花”（Calcium Spark），原始论文曾被誉为100多年来十篇最杰出的心肌研究论文之一； ② 发现线粒体 “超氧炫”又称“线粒体炫”（Mitoflash），揭示其在能量代谢、学习记忆及衰老生物学中的信号功能；③率团队研发2.2克微型双光子显微镜，实现了在自由活动小鼠观察大脑神经元活动，开启脑科学研究的新范式。该项成果获“2017年中国科学十大进展”，并入选Nature Methods“2018年度方法”。此外，获国际心脏学会“Research Achievement Award”(2016），国家自然科学奖二等奖（2017），何梁何利基金科学与技术进步奖（2020），北京大学2021年度国华杰出学者奖（2021），中国专利优秀奖（2022）等。

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BCEIA 2023 ‖ 学术报告会大会报告 2

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